PTC CLINIC
Information for Healthcare Professionals

The use of hadron radiotherapy in the treatment of ENT tumors has been described, for example, in the following studies:

1.     Tokuuye K, Akine Y, Kagei K, Hata M, Hashimoto T, Mizumoto T, Ohshiro Y, Sugahara S, Ohara K, Okumara T, Kusukari J, Yoshida H, Otsuka F. Proton therapy for head and neck malignancies at Tsukuba. Strahlentherapie und OnkologieT 2004; 180(2): 96-101.

2.     Murakami M, Niwa Y, Demizu Y, Miyawaki D, Terashima K, Arimura T, Hishikawa Y. Particle-beam radiation therapy for the tumor of pharyngeal region. IFMBE Proceedings 2009; 25(1): 25-28. (abstrakt)

3.     Chan AV, Liebsch AJ, Deschler DG, Adams JA, Vrishali JV, McIntyre LV, Pommier P, Fabian RL, Busse PM. Proton radiotherapy for T4 nasopharyngeal carcinoma. J Clin Oncol. 2004; 22:5574. (abstrakt)

4.     Lin R, Slater JD, Yonemoto LT, Grove RI, Teichman SL, Watt DK, Slater JM. Nasopharyngeal carcinoma: repeat treatment with conformal proton therapy—dose-volume histogram analysis. Radiology 1999, 213:489–494. (abstrakt)

5.     Slater JD, Yonemoto LT, Mantik DW, Bush DA, Preston W, Grove RI, Miller DW, Slater JM. Proton radiation for treatment of cancer of the oropharynx: early experience at Loma Linda University Medical Center using a concomitant boost technique. Int J Radiat Oncol Biol Phys. 2005; 62(2):494-500.

6.     Chan AW, Pommier P, Deschler DG, Liebsch NJ, McIntyre JF, Adams JA, Lopes VV, Frankenthaler RJ,  Fabian RL, Thornton AF. Change in patterns of relapse after combined proton and photon irradiation for locally advanced paranasal sinus cancer. Int J Radiat Oncol Biol Phys. 2004; 60(1):S320. (abstrakt)

7.     Zenda S, Kohno R, Kawashima M, Arahira S, Nishio T, Tahara M, Hayashi R, Kishimoto S, Ogino T. Proton beam therapy for unresectable malignancies of the nasal cavity and paranasal sinuses. Int J Radiat Oncol Biol Phys. 2011; 81(5):1473-8. (abstrakt)

8.     Zenda S.Proton Beam Therapy for Patients with Malignancies of The Nasal Cavity, Para-nasal Sinuses, and/or Involving the Skull Base: The Analysis of Late Toxicity. ASTRO 2011.

9.     Fitzek MM, Thornton AF, Varvares M, Ancukiewicz M, Mcintyre J, Adams J, Rosenthal S, Joseph M, Amrein P. Neuroendocrine tumors of the sinonasal tract. Results of
a prospective study incorporating chemotherapy, surgery, and combined proton-photon radiotherapy. Cancer. 2002; 94(10):2623-34.

10.     Weber DC, Chan AW, Lessell S, McIntyre JF, Goldberg SI, Bussiere MR, Fitzek MM, Thornton AF, Delaney TF. Visual outcome of accelerated fractionated radiation for advanced sinonasal malignancies employing photons/protons. Radiother Oncol 2006, 81:243–249.

11.     Takagi M. et al., Treatment outcomes of particle radiotherapy using protons or carbon ions as a single-modality therapy for adenoid cystic carcinoma of the head and neck. Radiother Oncol. 2014 Dec;113(3):364-70.

12.     Frank SJ et al. Multifield optimization intensity modulated proton therapy for head and neck tumors: a translation to practice., Int J Radiat Oncol Biol Phys. 2014 Jul 15;89(4):846-53.

13.     Patel SH, Wang Z, Wong WW, et al., Charged particle therapy versus photon therapy for paranasal sinus and nasal cavity malignant diseases: a systematic review and meta-analysis. Lancet Oncol. 2014 Aug;15(9):1027-38

14.     Verma V, Mishra MV, Mehta MP. A systematic review of the cost and cost-effectiveness studies of proton radiotherapy. Cancer. 2016 Feb 1.  doi: 10.1002/cncr.29882. [Epub ahead of print].

Literature on paranasal sinuses tumors:

• Toyomasu Y(1), Demizu Y(2), Matsuo Y(2), Sulaiman NS(2), Mima M(2), Nagano F(2), Terashima K(2), Tokumaru S(2), Hayakawa T(3), Daimon T(4), Fuwa N(5), Sakuma H(6), Nomoto Y(7), Okimoto T(2). Outcomes of Patients With Sinonasal Squamous Cell Carcinoma Treated With Particle Therapy Using Protons or Carbon Ions. Int J Radiat Oncol Biol Phys. 2018 Aug 1;101(5):1096-1103. doi:10.1016/j.ijrobp.2018.04.041. Epub 2018 Apr 22.
• Russo AL(1), Adams JA(1), Weyman EA(1), Busse PM(1), Goldberg SI(1), Varvares M(2), Deschler DD(2), Lin DT(2), Delaney TF(1), Chan AW(3). Long-Term Outcomes After Proton Beam Therapy for Sinonasal Squamous Cell Carcinoma. Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):368-76. doi: 10.1016/j.ijrobp.2016.02.042. Epub 2016 Feb 18.
• McDonald MW(1), Liu Y(2), Moore MG(3), Johnstone PA(4). Acute toxicity in comprehensive head and neck radiation for nasopharynx and paranasal sinus cancers: cohort comparison of 3D conformal proton therapy and intensity modulated radiation therapy. Radiat Oncol. 2016 Feb 27;11:32. doi: 10.1186/s13014-016-0600-3.
• Patel SH(1), Wang Z(2), Wong WW(3), Murad MH(2), Buckey CR(3), Mohammed K(2), Alahdab F(2), Altayar O(2), Nabhan M(2), Schild SE(3), Foote RL(4). Charged particle therapy versus photon therapy for paranasal sinus and nasal cavity malignant diseases: a systematic review and meta-analysis Lancet Oncol. 2014 Aug;15(9):1027-38. doi: 10.1016/S1470-2045(14)70268-2. Epub 2014 Jun 26.
• Fukumitsu N(1). Particle beam therapy for cancer of the skull base, nasal cavity, and paranasal sinus. ISRN Otolaryngol. 2012 May 31;2012:965204. doi: 10.5402/2012/965204. Print 2012.

Literature on nasopharyngeal tumors:

• Holliday EB(1), Frank SJ(2). Proton therapy for nasopharyngeal carcinoma. Chin Clin Oncol. 2016 Apr;5(2):25. doi: 10.21037/cco.2016.03.05.
• Uezono H(1), Indelicato DJ(1), Rotondo RL(1), Sandler ES(2), Katzenstein HM(2), Dagan R(1), Mendenhall WM(1), Mailhot Vega R(1), Brennan BM(3), Bradley JA(1). Proton therapy following induction chemotherapy for pediatric and adolescent nasopharyngeal carcinoma.Pediatr Blood Cancer. 2019 Dec;66(12):e27990. doi: 10.1002/pbc.27990. Epub 2019 Sep 16.
• Beddok A(1), Feuvret L(2), Noël G(3), Bolle S(4), Deberne M(5), Mammar H(6), Chaze A(7), Le Tourneau C(8), Goudjil F(6), Zefkili S(9), Herman P(10), Dendale R(11), Calugaru V(11). [Boost in proton for locally advanced nasopharyngeal carcinoma: A Curie Institute experience].Cancer Radiother. 2019 Jul;23(4):304-311. doi: 10.1016/j.canrad.2019.01.003. Epub 2019 May 25.
• Lewis GD(1), Holliday EB(1), Kocak-Uzel E(1)(2), Hernandez M(3), Garden AS(1), Rosenthal DI(1), Frank SJ(1). Intensity-modulated proton therapy for nasopharyngeal carcinoma: Decreased radiation dose to normal structures and encouraging clinical outcomes. Head Neck. 2016 Apr;38 Suppl 1:E1886-95. doi: 10.1002/hed.24341. Epub 2015 Dec 26.

Literature on salivary gland tumors:

• Orlandi E(1), Iacovelli NA(2), Bonora M(3), Cavallo A(4), Fossati P(5). Salivary Gland. Photon beam and particle radiotherapy: Present and future. Oral Oncol. 2016 Sep;60:146-56. doi: 10.1016/j.oraloncology.2016.06.019. Epub 2016 Jul 6
• Romesser PB(1), Cahlon O(2), Scher E(3), Zhou Y(4), Berry SL(1), Rybkin A(1),
• Sine KM(5), Tang S(5), Sherman EJ(6), Wong R(7), Lee NY(8). Proton beam radiation therapy results in significantly reduced toxicity compared with intensity-modulated radiation therapy for head and neck tumors that require ipsilateral radiation. Radiother Oncol. 2016 Feb;118(2):286-92. doi: 10.1016/j.radonc.2015.12.008. Epub 2016 Feb 8.
• Grant SR(1), Grosshans DR(2), Bilton SD(2), Garcia JA(2), Amin M(2), Chambers MS(2), McGovern SL(2), McAleer MF(2), Morrison WH(2), Huh WW(3), Kupferman ME(4), Mahajan A(5). Proton versus conventional radiotherapy for pediatric salivary gland tumors: Acute toxicity and dosimetric characteristics. Radiother Oncol. 2015 Aug;116(2):309-15. doi: 10.1016/j.radonc.2015.07.022. Epub 2015 Jul 28.

Literature on tonsil carcinoma:

• Meijer TWH(1), Scandurra D(1), Langendijk JA(1). Reduced radiation-induced toxicity by using proton therapy for the treatment of oropharyngeal cancer.Br J Radiol. 2020 Jan 23:20190955. doi: 10.1259/bjr.20190955. [Epub ahead of print]
• Sio TT(1), Lin HK(2), Shi Q(2), Gunn GB(3) Intensity Modulated Proton Therapy Versus Intensity Modulated Photon Radiation Therapy for Oropharyngeal Cancer: First Comparative Results of Patient-Reported Outcomes. Int J Radiat Oncol Biol Phys. 2016 Jul 15;95(4):1107-14. doi: 10.1016/j.ijrobp.2016.02.044. Epub 2016 Feb 18.
• Blanchard P(1), Garden AS(2), Gunn GB(2) Intensity-modulated proton beam therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for patients with oropharynx cancer – A case matched analysis. Radiother Oncol. 2016 Jul;120(1):48-55. doi: 10.1016/j.radonc.2016.05.022. Epub 2016 Jun 21.Gunn GB(1), Blanchard P(2), Garden AS(1) Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):360-7. doi: 10.1016/j.ijrobp.2016.02.021. Epub 2016 Feb 12.

Additional literature:

• Seidensaal K(1)(2)(3)(4), Harrabi SB(1)(2)(3)(4), Uhl M Re-irradiation with protons or heavy ions with focus on head and neck, skull base and brain malignancies. Br J Radiol. 2019 Nov 12:20190516. doi: 10.1259/bjr.20190516. [Epub ahead of print]
• McDonald MW(1), Zolali-Meybodi O(2), Lehnert SJ(2) Reirradiation of Recurrent and Second Primary Head and Neck Cancer With Proton Therapy. Int J Radiat Oncol Biol Phys. 2016 Nov 15;96(4):808-819. doi: 10.1016/j.ijrobp.2016.07.037. Epub 2016 Aug 3.
• Phan J(1), Sio TT(2), Nguyen TP(1), Takiar V(3) Reirradiation of Head and Neck Cancers With Proton Therapy: Outcomes andAnalyses.Int J Radiat Oncol Biol Phys. 2016 Sep 1;96(1):30-41. doi:10.1016/j.ijrobp.2016.03.053. Epub 2016 Apr 13.