The main advantage of proton therapy is in the appreciably better radiation distribution, owing to which improved treatment results can be achieved while reducing toxicity of the therapy. The improved dose distribution patterns provide the opportunity to apply higher doses without inducing more severe side effects.
Proton therapy applied by following the PTC protocol offers:
Figure 1: Example of an irradiation plan and dose distribution to individual organs. It is clear that a significantly lower dose is applied to healthy brain tissue during proton radiotherapy.
Table 1: Doses to the various structures/organs.
IMRT (photons) | IMPT (protons) | |
Target volume (brain tumor) | 60 Gy (100%) | 60 Gy (100%) |
Brain (Dmean) | 35.7 Gy (59.5%) | 25.9 Gy (43.1%) |
Brain stem (Dmean) | 18.6 Gy (31%) | 5.3 Gy (8.8%) |
Right eye (Dmean) | 28.3 Gy (47.2%) | 9.7 Gy (16.2%) |
Chiasma opticum (Dmax) | 49.0 Gy (81.6%) | 46.0 Gy (76.6%) |
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